Human/sleep laboratories


Service | Instruments | Publications

Human and sleep laboratories are available for studies for the research groups at CBBM.

Reservations can be made in consultation with Dr. Matthias Mölle HERE  (login required!).

All human/sleep labs consist of a separate room for neuroscientific studies with one or more subjects. The labs provide sufficient space for equipment and computer workstations and can be closed with an opaque door. Observation of subjects via video camera and interaction via intercom is possible from the adjacent monitoring rooms.

The laboratories are bright, high rooms, which are supplied with daylight either by a generous glass front to the atrium of the CBBM or a window front to the outside. All laboratories have electrically operated darkening. Some of the laboratories are equipped with comfortable hospital beds for sleep studies. Several portable and stationary 32 channel EEG units are available. An opening in the wall allows cables to pass through to equipment in the monitoring room and tubing for remote blood sampling. All labs have a separate wet room with shower, sink and toilet.

Service

  • Instruction in EEG recording in humans
  • Instruction in sleep studies in humans
  • Assistance in setting up neuroscientific experimental setups
  • Sleep EEG analysis
  • Evoked potential analysis
  • EEG frequency analysis
  • Programming of stimulation experiments using PsychoPy

Instruments

  • BrainAmp DC and BrainAmp EXG, stationary 32-channel EEG amplifiers plus 16-channel amplifiers for bipolar and peripheral signals
  • LiveAmp and LiveAmp Sensor & Trigger Extension, portable and compact 32 channel EEG amplifier plus 8 channel amplifier for bipolar and peripheral signals and trigger extension (enables 8-bit trigger)

Publications

  • Aksamaz S, Mölle M, Akinola EO, Gromodka E, Bazhenov M, Marshall L (2023) Single closed-loop acoustic stimulation targeting memory consolidation suppressed hippocampal ripple and thalamo-cortical spindle activity in mice. Eur J Neurosci. 
  • Friedrich M, Mölle M, Born J, Friederici AD (2022) Memory for nonadjacent dependencies in the first year of life and its relation to sleep. Nat Commun 13:7896.
  • Koo-Poeggel P, Neuwerk S, Petersen E, Grasshoff J, Mölle M, Martinetz T, Marshall L (2022) Closed-loop acoustic stimulation during an afternoon nap to modulate subsequent encoding. J Sleep Res 31:e13734.
  • Mushtaq M, Marshall L, Bazhenov M, Mölle M, Martinetz T (2022) Differential thalamocortical interactions in slow and fast spindle generation: A computational model. PLoS One 17:e0277772.
  • Chamorro R, Wilms B, Holst A, Röhl C, Mölle M, Knaak A, Meyhöfer S, Lehnert H, Schmid SM (2021) Acute mild dim light at night slightly modifies sleep but does not affect glucose homeostasis in healthy men. Sleep Med 84:158-164.
  • Weber FD, Supp GG, Klinzing JG, Mölle M, Engel AK, Born J (2021) Coupling of gamma band activity to sleep spindle oscillations - a combined EEG/MEG study. Neuroimage 224:117452.
  • Friedrich M, Mölle M, Friederici AD, Born J (2020) Sleep-dependent memory consolidation in infants protects new episodic memories from existing semantic memories. Nat Commun 11:1298.
  • Prehn-Kristensen A, Ngo HV, Lentfer L, Berghäuser J, Brandes L, Schulze L, Göder R, Mölle M, Baving L (2020) Acoustic closed-loop stimulation during sleep improves consolidation of reward-related memory information in healthy children but not in children with attention-deficit hyperactivity disorder. Sleep 43.
  • Wilms B, Kuhr M, Chamorro R, Klinsmann N, Spyra D, Mölle M, Kalscheuer H, Schultes B, Lehnert H, Schmid SM (2020) Chronobiological aspects of sleep restriction modulate subsequent spontaneous physical activity. Physiol Behav 215:112795.
  • Binder S, Mölle M, Lippert M, Bruder R, Aksamaz S, Ohl F, Wiegert JS, Marshall L (2019) Monosynaptic Hippocampal-Prefrontal Projections Contribute to Spatial Memory Consolidation in Mice. J Neurosci 39:6978-6991.
  • Friedrich M, Mölle M, Friederici AD, Born J (2019) The reciprocal relation between sleep and memory in infancy: Memory-dependent adjustment of sleep spindles and spindle-dependent improvement of memories. Dev Sci 22:e12743.
  • Ngo HV, Seibold M, Boche DC, Mölle M, Born J (2019) Insights on auditory closed-loop stimulation targeting sleep spindles in slow oscillation up-states. J Neurosci Methods 316:117-124.
  • Wilms B, Chamorro R, Hallschmid M, Trost D, Forck N, Schultes B, Mölle M, Sayk F, Lehnert H, Schmid SM (2019) Timing Modulates the Effect of Sleep Loss on Glucose Homeostasis. J Clin Endocrinol Metab 104:2801-2808.
  • Wilms B, Leineweber EM, Mölle M, Chamorro R, Pommerenke C, Salinas-Riester G, Sina C, Lehnert H, Oster H, Schmid SM (2019) Sleep Loss Disrupts Morning-to-Evening Differences in Human White Adipose Tissue Transcriptome. J Clin Endocrinol Metab 104:1687-1696.
  • Koo PC, Mölle M, Marshall L (2018) Efficacy of slow oscillatory-transcranial direct current stimulation on EEG and memory - contribution of an inter-individual factor. Eur J Neurosci 47:812-823.
  • Friedrich M, Wilhelm I, Mölle M, Born J, Friederici AD (2017) The Sleeping Infant Brain Anticipates Development. Curr Biol 27:2374-2380.e2373.