Metabolic Core Unit (MCU)

 

The Metabolic Core Unit (MCU) of the CBBM, as part of the human/sleep laboratories, is available to all working groups in the CBBM for research studies. State-of-the art measurements on body composition and energy consumption of test persons can be performed. 


The following examinations can be carried out:

  • Dual Energy X-ray Absorptiometry

DEXA measurements are the gold standard to determine to measure total body composition.

 

  • Air Displacement Plethysmography (BOD POD)

Using air displacement plethysmograph the body composition (fat and fat-free mass) can be determined.

 

  • Indirect Calorimetry

By measuring oxygen uptake (O2) and carbon dioxide production (CO2) energy expenditure can be analyzed.

Publications

  • Pointke M, Strenge F, Piotrowski D, Matteikat A, Meyhöfer S, Meyhöfer SM, Chamorro R, Wilms B. Short-term high-fat and high-carb diet effects on glucose metabolism and hedonic regulation in young healthy men. Front Nutr 2024;11:1469230
  • Rippe W, Weisner L, Ewen J, Mench P, Koppius T, Borgwardt S, Tari B, Heath M, Sprenger A, Wilms B, Lencer R. We like to move it - patients with schizophrenia spectrum disorders are impaired in estimating their physical fitness levels and benefit from individualized exercise. Eur Arch Psychiatry Clin Neurosci 2024 Online ahead of print,
  • Prasuhn J, Schiefen T, Güber T, Henkel J, Uter J, Steinhardt J, Wilms B, Brüggemann. Levodopa Impairs the Energy Metabolism of the Basal Ganglia In Vivo. Ann Neurol 2024;95(5):849-857.
  • Steinhardt J, Lokowandt L, Rasche D, Koch A, Tronnier V, Münte TF, Meyhöfer SM, Wilms B, Brüggemann. Mechanisms and consequences of weight gain after deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease. Sci Rep 2023;13(1):14202.
  • Meyhöfer S, Chamorro R, Hallschmid M, Spyra D, Klinsmann N, Schultes B, Lehnert H, Meyhöfer SM, Wilms B. Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food. Nutrients 2023;15(9):2035.
  • Meyhöfer S, Wilms B, Chamorro R, Knaak A, Pappa E, Schulz AS, Pagels AJ, Schröder M, Kaluzny N, Grein HJ, Meyhöfer SM. Metabolic Status Modulates Choroidal Thickness - A Possible Early Indicator for Diabetic Eye Complications? Exp Clin Endocrinol Diabetes 2022;130(12):789-792.
  • Chamorro R, Kannenberg S, Wilms B, Kleinerüschkamp C, Meyhöfer S, Park SQ, Lehnert H, Oster H, Meyhöfer SM. Meal Timing and Macronutrient Composition Modulate Human Metabolism and Reward-Related Drive to Eat. Nutrients 2022;14(3):562.
  • Chamorro R, Wilms B, Holst A, Röhl C, Mölle M, Knaak A, Meyhöfer S, Lehnert H, Schmid SM. Acute mild dim light at night slightly modifies sleep but does not affect glucose homeostasis in healthy men. Sleep Med 2021;84:158-164.
  • Wilms B, Kuhr M, Chamorro R, Klinsmann N, Spyra D, Mölle M, Kalscheuer H, Schultes B, Lehnert H, Schmid SM. Chronobiological aspects of sleep restriction modulate subsequent spontaneous physical activity. Physiol Behav 2020;215:112795.
  • Meyhöfer S, Wilms B, Ihling F, Windjäger A, Kalscheuer H, Augustinov A, Herrmann V, Lehnert H, Schmid SM. Evaluation of a near-infrared light ultrasound system as a non-invasive blood glucose monitoring device. Diabetes Obes Metab 2020;22(4):694-698.
  • Wilms B, Chamorro R, Hallschmid M, Trost D, Forck N, Schultes B, Mölle M, Sayk F, Lehnert H, Schmid SM. Timing Modulates the Effect of Sleep Loss on Glucose Homeostasis. J Clin Endocrinol Metab 2019;104(7):2801-2808
  • Wilms B, Leineweber EM, Mölle M, Chamorro R, Pommerenke C, Salinas-Riester G, Sina C, Lehnert H, Oster H, Schmid SM. Sleep Loss Disrupts Morning-to-Evening Differences in Human White Adipose Tissue Transcriptome. J Clin Endocrinol Metab 2019;104(5):1687-1696.